KMID : 0363620050260040098
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Journal of Korean Oriental Medicine 2005 Volume.26 No. 4 p.98 ~ p.107
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Effect of Acupuncture on 6-Hydroxydopamine-induced Nigrostriatal Dopaminergic Neuronal Cell Death in Rats
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Kim YK
Song YK/Lim HH
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Abstract
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Objectives: Acupuncture treatment has been clinically used for functional recovery in Parkinson¡¯¡¯s disease. In the present study, we investigated the effect of acupuncture at Zusanli (ST36) on nigrostriatal dopaminergic neuronal cell death in rats.
Methods: A Parkinson¡¯¡¯s disease model was induced by the unilateral injection of 6-hydroxydopamine (6-OHDA) into the striatum. Acupuncture treatment was performed at Zusanli (ST36) and at the hip, as a non-acupoint, once a day for 14 days. Two weeks after 6-0HDA injection, an apomorphine-induced rotational behavior test showed significant rotational asymmetry in rats with Parkinson¡¯¡¯s disease. Immunostaining for tyrosine hydroxylase demonstrated a dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum.
Results: Acupuncture at the ST36 acupoint significantly inhibited rotational asymmetry in rats with Parkinson¡¯¡¯s disease, and also protected against 6-OHDA-induced nigrostriatal dopaminergic neuronal loss. These effects of acupuncture were not observed for non-acupoint acupuncture.
Conclusions: The present study shows that acupuncture treatment, especially at the ST36 acupoint, can be used as a useful strategy for the treatment of Parkinson¡¯¡¯s disease.
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